Other adverse
effects reported in pre-approval research
included:- Shrunken thymus glands (up to 40% shrinkage)
(EO56) - Enlarged liver and kidneys. (EO57 &
E161) - Atrophy of lymph follicles in the spleen and
thymus (EO51, EO56, EO151) - Increased cecal weight (E151)
- Reduced growth rate (EO57)
- Decreased red blood
cell count (EO55) - Hyperplasia of the pelvis (EO57)
- Extension of the pregnancy period
- Aborted pregnancy (E134)
- Decreased fetal body weights and placental
weights (EO32) - Diarrhea
- Shrunken thymus glands (up to 40% shrinkage)
- Recent Research
a possible problem with
caecal enlargement and renal mineralization has been seen in
post approval animal research. - Sucralose Breaks Down
Despite the
manufacturer's misstatements, sucralose does break down into
small amounts of 1, 6-dichlorofructose, a chemical that has not
been adequately tested in humans. - Independent, Long-Term Human Research
None. Manufacturer's "100's of studies" (some of which show
hazards) were clearly inadequate and do not demonstrate safety
in long-term use. - Chlorinated Pesticides
the manufacturer
claims that the chlorine added to sucralose is similar to the
chlorine atom in the salt (NaCl) molecule. That is not the
case. Sucralose may be more like ingesting tiny amounts of
chlorinated pesticides, but we will never know without
long-term, independent human research. - Conclusion
While it is unlikely that
sucralose is as toxic as the poisoning people are experiencing
from Monsanto's ,
it is clear from the hazards seen in pre-approval research and
from its chemical structure that years or decades of use may
contribute to serious chronic immunological or neurological
disorders. - Addendum (October 2, 2006)
occasionally,
persons emailing ask questions about sucralose research. What
follows is a copy of a response one such question.
The answer starts by summarizing the aspartame
(NutraSweet) issue and then addresses the sucralose
issue.
Let me start by saying that, as you may know, there
is a quickly growing body of evidence demonstrating the
toxicity of aspartame.
This includes:
- Recent European research showing that ingesting
aspartame leads to the accumulation of formaldehyde in the
brain, other organs and tissues (Formaldehyde has been shown
to damage the nervous system, immune system, and cause
irreversible genetic damage in humans.) - An extremely large number of toxicity reactions
reported to the FDA and other organizations - A recent report showing that nearly 100% of
independent research has found problems with
aspartame.
Why is this relevant to the sucralose question? Similar to the
aspartame situation 15 years ago:
- Pre-approval test
indicated potential toxicity of sucralose. - There are no *independent* controlled human studies
on sucralose (similar to 15 years ago for
aspartame). - There are no long-term (12-24 months) human studies
of sucralose's effects. - There is no monitoring of health effects. It took
government agencies decades to agree that there were
countless thousands of deaths from tobacco. Why? Simply
because there had been no monitoring or epidemiological
studies. Without such monitoring and studies, huge effects
can easily go unnoticed.
So, without even addressing the
pre-approval research showing potential toxicity, it is clear
that sucralose has a) no long history (e.g., decades) of safe
use, b) no independent monitoring of health effects, c) no
long-term human studies, and d) no independent human studies. I
would hope that the Precautionary Principle, now commonly used
in Europe, would be a guiding force for people who are
interested in health. Otherwise, we might as well just use any
poorly tested, artificial (lab-created) chemical that has shown
potential for long-term toxicity.
As far as the pre-approval research related to
sucralose…. As you probably know, pre-approval research is
rarely published. It is only available from the FDA by filing a
Freedom of Information Act request. However, you can see a very
short summary regarding sucralose and shrunken thymus glands in
the "New Scientist" (23 November 1991, page 13).
It is very important that people who have any interest
in their health stay aware from
the highly toxic sweetener, aspartame
and other dangerous sweeteners such as sucralose (Splenda),
and acesulfame-k (Sunette, Sweet & Safe, Sweet One). Instead,
please see the extensive resources for sweeteners on the
Healthier Sweetener Resource
List.
Sources:
Available on request.
Dr. Félix E. F. Larocca
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